.xlsx file cannot open in excel 2010 by double clicking

I believe this to be registry related issue.

So, it should be possible to use Registry to fix it.
You could try using regedit.

1.Click on the "Start" button, and then click on "Run." In the dialog box that appears, type "regedit" into the text box, and then click the "OK" button.
2.Navigate to
           HKEY_CLASSES_ROOT\Applications\EXCEL.EXE\shell\open\command
3. change to Office14. 


Some times Its not solve the issue..

At that time Please try to remove the "%1" in the registry key and try..
Then change the default proramme of the .xlsx file to excel.
After that open regedit and add "%1" at the end again.

Then check and enjoy working....